Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1436 410 0.1702 0.2268 0.2855 0.2365
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 1 751 26 0.6268 0.4801 0.0346 0.0405
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 2 577 29 0.4738 0.4801 0.0503 0.0405
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 831 38 0.7851 1.0000 0.0457 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1129 54 1.0644 1.0000 0.0478 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1533 83 1.4356 1.3614 0.0541 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 945 46 0.8901 0.7459 0.0487 0.0510
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 6098 771 0.8836 1.0000 0.1264 0.1402
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 562 31 0.5257 0.7459 0.0552 0.0510
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 7489 1113 1.0576 1.0000 0.1486 0.1402
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 518 32 0.4812 0.7521 0.0618 0.0500
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 7471 1087 1.0589 1.0000 0.1455 0.1402
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 3443 247 0.9587 1.0000 0.0717 0.0694
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 15785 755 0.9659 1.0000 0.0478 0.0508
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 18392 833 1.0430 1.0000 0.0453 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 18289 776 1.0403 1.0000 0.0424 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 16139 705 0.9168 1.0000 0.0437 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 13521 729 0.7598 0.8466 0.0539 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 15518 786 0.8751 0.8466 0.0507 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 16012 776 0.9050 0.8466 0.0485 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 9338 344 0.5342 0.4663 0.0368 0.0378
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 7768 292 0.4441 0.4663 0.0376 0.0378
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 7367 288 0.4205 0.4663 0.0391 0.0378
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2061 127 0.5801 0.3687 0.0616 0.0639
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 759 27 0.2196 0.2356 0.0356 0.0441