Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1767 946 0.2167 0.2059 0.5354 0.5413
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1607 889 0.1895 0.2059 0.5532 0.5413
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 1 830 691 0.0341 0.0282 0.8325 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 2 760 668 0.0226 0.0282 0.8789 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 3 781 667 0.0280 0.0282 0.8540 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 1 761 664 0.0238 0.0332 0.8725 0.8226
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 2 802 672 0.0319 0.0332 0.8379 0.8226
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 1.0000
uM
 72
hr
 3 738 559 0.0439 0.0332 0.7575 0.8226
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 1 1670 252 0.1072 0.1011 0.1509 0.1391
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 2 1510 221 0.0975 0.1011 0.1464 0.1391
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 3 1482 178 0.0986 0.1011 0.1201 0.1391
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 1 1033 589 0.0336 0.0434 0.5702 0.4431
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 2 1083 387 0.0526 0.0434 0.3573 0.4431
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 3 971 390 0.0439 0.0434 0.4016 0.4431
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 926 169 0.0450 0.0479 0.1825 0.1891
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 978 183 0.0472 0.0479 0.1871 0.1891
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1083 214 0.0516 0.0479 0.1976 0.1891
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 1174 182 0.0589 0.0738 0.1550 0.1567
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1575 236 0.0795 0.0738 0.1498 0.1567
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1675 277 0.0830 0.0738 0.1654 0.1567
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1009 535 0.1422 0.2129 0.5302 0.5118
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1480 738 0.2226 0.2129 0.4986 0.5118
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1850 937 0.2739 0.2129 0.5065 0.5118
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 515 127 0.1164 0.1044 0.2466 0.2680
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 446 133 0.0939 0.1044 0.2982 0.2680