Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 3306 212 0.8166 0.8396 0.0641 0.0716
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2965 234 0.7208 0.7205 0.0789 0.0832
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2722 220 0.6603 0.7205 0.0808 0.0832
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2870 305 0.1452 0.1203 0.1063 0.1099
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1474 97 1.3027 1.3504 0.0658 0.0554
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1272 531 0.1043 0.1328 0.4175 0.4089
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1585 85 1.4191 1.3504 0.0536 0.0554
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2274 274 0.1132 0.1203 0.1205 0.1099
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 683 22 0.6254 0.7364 0.0322 0.0453
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 875 41 0.7890 0.7329 0.0469 0.0348
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 506 12 0.4674 0.7329 0.0237 0.0348
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2021 208 0.1026 0.1203 0.1029 0.1099
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2628 502 0.3526 0.2882 0.1910 0.1748
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 3916 531 0.5667 0.5804 0.1356 0.1393
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1436 410 0.1702 0.2268 0.2855 0.2365
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2110 97 0.1294 0.1268 0.0460 0.0491
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 6098 771 0.8836 1.0000 0.1264 0.1402
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 7489 1113 1.0576 1.0000 0.1486 0.1402
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 7471 1087 1.0589 1.0000 0.1455 0.1402
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 1546 216 0.2206 0.2071 0.1397 0.1768
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 1442 278 0.1931 0.2071 0.1928 0.1768
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 2178 499 0.2785 0.2268 0.2291 0.2365
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1735 338 0.2317 0.2268 0.1948 0.2365
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1496 94 0.4792 1.0367 0.0628 0.0669
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 3369 247 1.0671 1.0367 0.0733 0.0669