Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 4796 182 0.2741 0.3895 0.0379 0.0403
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 19598 815 1.1074 1.0240 0.0416 0.0404
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 11842 391 0.6751 0.6666 0.0330 0.0291
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 3633 273 0.8711 0.8287 0.0751 0.0771
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 11776 362 0.6729 0.6666 0.0307 0.0291
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 15081 869 0.8042 0.8521 0.0576 0.0546
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 11320 265 0.6518 0.6666 0.0234 0.0291
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 3 5354 726 0.9013 1.0000 0.1356 0.1347
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 6910 334 0.3877 0.3181 0.0483 0.0472
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 16146 916 0.8618 0.8521 0.0567 0.0546
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 5428 243 0.3057 0.3181 0.0448 0.0472
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 4651 226 0.2609 0.3181 0.0486 0.0472
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 15978 849 0.9722 1.0000 0.0531 0.0508
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 16548 819 0.8901 0.8521 0.0495 0.0546
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 6192 876 1.0352 1.0000 0.1415 0.1347
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 9628 474 0.5180 0.5111 0.0492 0.0493
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 5372 829 0.6394 0.5738 0.1543 0.1547
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 4420 267 1.0342 0.9709 0.0604 0.0651
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 4110 265 0.9575 0.9709 0.0645 0.0651
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 9606 487 0.5160 0.5111 0.0507 0.0493
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 5080 829 0.8278 0.9999 0.1632 0.1645
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 3999 254 0.2407 0.2809 0.0635 0.0601
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 3564 170 0.8945 0.9655 0.0477 0.0440
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 5474 256 1.3752 0.9655 0.0468 0.0440