Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 7367 288 0.4205 0.4663 0.0391 0.0378
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1575 62 1.4609 1.3505 0.0394 0.0426
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 579 23 0.5505 0.6713 0.0397 0.0438
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2009 80 0.1240 0.1595 0.0398 0.0410
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 18030 727 1.0201 1.0000 0.0403 0.0484
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1114 46 1.0312 1.0000 0.0413 0.0416
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1256 52 1.1921 1.3614 0.0414 0.0486
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 628 26 0.5813 0.6350 0.0414 0.0435
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 3039 126 0.1872 0.1595 0.0415 0.0410
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 530 22 0.5030 0.7059 0.0415 0.0474
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 19598 815 1.1074 1.0240 0.0416 0.0404
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2717 113 0.1673 0.1595 0.0416 0.0410
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 3923 164 0.9907 0.9208 0.0418 0.0457
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 18289 776 1.0403 1.0000 0.0424 0.0438
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 872 37 0.8267 0.7521 0.0424 0.0500
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1538 67 1.4203 1.3505 0.0436 0.0426
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 16139 705 0.9168 1.0000 0.0437 0.0438
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 725 32 0.6691 0.6350 0.0441 0.0435
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 18988 841 1.0699 1.0240 0.0443 0.0404
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 1712 76 1.4144 1.2637 0.0444 0.0426
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 5428 243 0.3057 0.3181 0.0448 0.0472
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1269 57 1.1703 1.3505 0.0449 0.0426
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1710 77 0.4899 0.3534 0.0450 0.0527
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 710 32 0.6547 0.6350 0.0451 0.0435
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 2 16108 728 1.1037 1.0000 0.0452 0.0842