Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 710 32 0.6547 0.6350 0.0451 0.0435
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 11320 265 0.6518 0.6666 0.0234 0.0291
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 1 2490 221 0.6505 0.6307 0.0888 0.0825
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2729 242 0.6447 0.6483 0.0887 0.0808
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 2 2431 184 0.6441 0.6307 0.0757 0.0825
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2655 180 0.6416 0.6483 0.0678 0.0808
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 684 37 0.6406 0.7059 0.0541 0.0474
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 5372 829 0.6394 0.5738 0.1543 0.1547
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 2821 227 0.6344 0.5869 0.0805 0.0856
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 1 751 26 0.6268 0.4801 0.0346 0.0405
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 2471 93 0.6267 0.9655 0.0376 0.0440
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 683 22 0.6254 0.7364 0.0322 0.0453
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2300 197 0.6241 0.5409 0.0857 0.0829
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 671 25 0.6238 0.6505 0.0373 0.0426
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 2 897 272 0.6188 0.5696 0.3032 0.3054
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 1 9641 818 0.6126 0.5250 0.0848 0.0831
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 2 9244 871 0.6009 0.5962 0.0942 0.0732
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 1857 107 0.5982 0.7564 0.0576 0.0560
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 3 2273 189 0.5974 0.6307 0.0832 0.0825
COLO 858 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 1 2817 383 0.5973 0.4915 0.1360 0.1414
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2177 201 0.5864 0.5728 0.0923 0.0984
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 857 266 0.5851 0.4168 0.3104 0.2703
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 4239 762 0.5821 0.4939 0.1798 0.1677
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 628 26 0.5813 0.6350 0.0414 0.0435
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 4932 1088 0.5803 0.5134 0.2206 0.2019