Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 1 1324 1269 0.0157 0.0146 0.9585 0.9538
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1598 1262 0.0473 0.0435 0.7897 0.7870
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 3 1579 1242 0.0509 0.0532 0.7866 0.7386
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 3 1402 1236 0.0251 0.0186 0.8816 0.9092
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 1274 1219 0.0107 0.0091 0.9568 0.9558
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1337 1219 0.0196 0.0145 0.9117 0.9231
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1524 1214 0.0514 0.0529 0.7966 0.7685
A-375 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 21851 1210 1.0372 1.0000 0.0554 0.0502
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1237 1209 0.0046 0.0049 0.9774 0.9743
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 1 1491 1204 0.0433 0.0226 0.8075 0.8932
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1330 1201 0.0182 0.0136 0.9030 0.9358
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1240 1189 0.0072 0.0087 0.9589 0.9527
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 8288 1188 1.0719 1.0000 0.1433 0.1414
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 1 1403 1186 0.0328 0.0286 0.8453 0.8489
COLO 858 Vemurafenib Trametinib Belinostat 0.0000 0.0000 0.0000
uM
 72
hr
 3 6638 1181 1.1834 1.0000 0.1779 0.1777
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1509 1177 0.0467 0.0435 0.7800 0.7870
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 1 1324 1177 0.0222 0.0219 0.8890 0.8885
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 1238 1176 0.0121 0.0135 0.9499 0.9372
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1204 1175 0.0048 0.0045 0.9759 0.9731
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 7119 1168 1.1589 0.9999 0.1641 0.1645
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 7512 1166 0.8932 0.9286 0.1552 0.1630
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 2 1738 1161 0.1437 0.1262 0.6680 0.6643
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 3 1291 1160 0.0198 0.0219 0.8985 0.8885
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1461 1159 0.0506 0.0484 0.7933 0.7812
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 2097 1153 0.2801 0.2264 0.5498 0.5573