Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 6061 346 1.6960 1.4011 0.0571 0.0616
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 5152 346 1.4263 1.4011 0.0672 0.0616
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1533 83 1.4356 1.3614 0.0541 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1549 78 1.4564 1.3614 0.0504 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1256 52 1.1921 1.3614 0.0414 0.0486
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1575 62 1.4609 1.3505 0.0394 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1538 67 1.4203 1.3505 0.0436 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1269 57 1.1703 1.3505 0.0449 0.0426
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1585 85 1.4191 1.3504 0.0536 0.0554
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1474 97 1.3027 1.3504 0.0658 0.0554
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1474 69 1.3292 1.3504 0.0468 0.0554
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 1446 46 1.3861 1.3106 0.0318 0.0383
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 1293 49 1.2317 1.3106 0.0379 0.0383
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 1390 63 1.3139 1.3106 0.0453 0.0383
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 5047 236 1.1830 1.2673 0.0468 0.0549
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 5542 297 1.2898 1.2673 0.0536 0.0549
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 5776 371 1.3291 1.2673 0.0642 0.0549
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 1712 76 1.4144 1.2637 0.0444 0.0426
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 1192 39 0.9968 1.2637 0.0327 0.0426
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 1681 85 1.3798 1.2637 0.0506 0.0426
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1496 94 0.4792 1.0367 0.0628 0.0669
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 3369 247 1.0671 1.0367 0.0733 0.0669
MZ7-mel Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 4890 315 1.5637 1.0367 0.0644 0.0669
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 15733 557 0.8947 1.0240 0.0354 0.0404
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 18988 841 1.0699 1.0240 0.0443 0.0404