Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 11776 362 0.6729 0.6666 0.0307 0.0291
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 11320 265 0.6518 0.6666 0.0234 0.0291
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 671 25 0.6238 0.6505 0.0373 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 483 25 0.4422 0.6505 0.0518 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 954 37 0.8854 0.6505 0.0388 0.0426
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2729 242 0.6447 0.6483 0.0887 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2779 239 0.6585 0.6483 0.0860 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2655 180 0.6416 0.6483 0.0678 0.0808
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 710 32 0.6547 0.6350 0.0451 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 628 26 0.5813 0.6350 0.0414 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 725 32 0.6691 0.6350 0.0441 0.0435
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 3 2273 189 0.5974 0.6307 0.0832 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 2 2431 184 0.6441 0.6307 0.0757 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 1 2490 221 0.6505 0.6307 0.0888 0.0825
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 794 27 0.6631 0.6202 0.0340 0.0473
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 859 40 0.7081 0.6202 0.0466 0.0473
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 603 37 0.4893 0.6202 0.0614 0.0473
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 3 7553 690 0.4925 0.5962 0.0914 0.0732
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 2 9244 871 0.6009 0.5962 0.0942 0.0732
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 1 10027 340 0.6952 0.5962 0.0339 0.0732
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 2821 227 0.6344 0.5869 0.0805 0.0856
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 2538 211 0.5691 0.5869 0.0831 0.0856
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 2513 234 0.5573 0.5869 0.0931 0.0856
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 4507 587 0.6563 0.5804 0.1302 0.1393
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 3916 531 0.5667 0.5804 0.1356 0.1393