Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 974 236 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1286 479 0.0457 0.0422 0.3725 0.3824
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1100 421 0.0384 0.0422 0.3827 0.3824
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1232 483 0.0424 0.0422 0.3920 0.3824
A-375 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 3 1163 292 0.0514 0.0531 0.2511 0.2566
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1146 415 0.0414 0.0486 0.3621 0.3602
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2009 80 0.1240 0.1595 0.0398 0.0410
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1031 185 0.0544 0.0441 0.1794 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 818 134 0.0440 0.0441 0.1638 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 628 100 0.0339 0.0441 0.1592 0.1675
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2021 208 0.1026 0.1203 0.1029 0.1099
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2274 274 0.1132 0.1203 0.1205 0.1099
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2870 305 0.1452 0.1203 0.1063 0.1099
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 3039 126 0.1872 0.1595 0.0415 0.0410
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1460 527 0.0528 0.0486 0.3610 0.3602
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 5428 243 0.3057 0.3181 0.0448 0.0472
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 4651 226 0.2609 0.3181 0.0486 0.0472
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 997 194 0.0516 0.0393 0.1946 0.1867
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2717 113 0.1673 0.1595 0.0416 0.0410
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1087 164 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 983 145 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 822 132 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 519 103 0.0267 0.0393 0.1985 0.1867
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 966 247 0.0361 0.0372 0.2557 0.2503
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 1108 292 0.0410 0.0372 0.2635 0.2503