Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 4796 182 0.2741 0.3895 0.0379 0.0403
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 975 952 0.0038 0.0030 0.9764 0.9776
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 717 700 0.0028 0.0030 0.9763 0.9776
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 707 693 0.0023 0.0030 0.9802 0.9776
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 978 183 0.0472 0.0479 0.1871 0.1891
COLO 858 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1667 265 0.2325 0.2882 0.1590 0.1748
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1106 1013 0.0131 0.0124 0.9159 0.9154
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 958 901 0.0080 0.0069 0.9405 0.9329
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 6910 334 0.3877 0.3181 0.0483 0.0472
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 817 124 0.0412 0.0422 0.1518 0.1591
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1074 145 0.0552 0.0473 0.1350 0.1511
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 927 141 0.0467 0.0473 0.1521 0.1511
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 806 134 0.0399 0.0473 0.1663 0.1511
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 4651 226 0.2609 0.3181 0.0486 0.0472
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 977 934 0.0072 0.0072 0.9560 0.9542
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 804 126 0.0403 0.0422 0.1567 0.1591
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1595 664 0.1310 0.1328 0.4163 0.4089
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1908 750 0.1630 0.1328 0.3931 0.4089
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1272 531 0.1043 0.1328 0.4175 0.4089
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 781 744 0.0062 0.0058 0.9526 0.9500
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1031 185 0.0544 0.0441 0.1794 0.1675
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1014 920 0.0132 0.0125 0.9073 0.9113
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 913 154 0.0451 0.0422 0.1687 0.1591
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 396 198 0.1712 0.1726 0.5000 0.4923
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 482 229 0.2187 0.1726 0.4751 0.4923