Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 4 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen class. - Dataset (ID:20271)

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  • 15 records
Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
ErbB
 3.6638 32.1056 100.0000 -0.1689 0.3761 0.7903 -0.7615 -0.0467 0.7365 0.2414 0.8924 1.8931 0.0426 0.1225 0.2901 3.5238 25.0142 100.0000
HDAC
 0.6637 10.5458 100.0000 -0.9162 -0.8279 -0.6812 -0.9386 -0.7986 -0.5940 1.1515 1.3812 1.9363 0.4324 0.5780 0.7387 1.4887 17.4169 100.0000
MAPK
 11.6591 100.0000 100.0000 0.2434 0.6068 0.8284 -0.1401 0.2970 0.7945 0.0000 0.6473 2.0118 0.0505 0.1028 0.2282 1.8870 54.0274 100.0000
MTOR
 0.0254 0.4517 7.7531 -0.7821 -0.4280 -0.0135 -1.0000 -0.7571 -0.1062 0.2867 0.4271 0.7139 0.3499 0.4986 0.6806 0.0350 3.5401 23.4064
NFKB
 3.2733 39.3712 100.0000 -0.8466 0.4657 0.8670 -0.8900 0.4520 0.8636 0.0000 1.4693 3.2926 0.0294 0.1585 0.3917 3.9583 8.2035 100.0000
PI3K
 0.0392 0.5181 82.8190 -0.4209 0.2753 0.5279 -0.6483 0.0343 0.4680 0.5394 0.8098 2.4996 0.1260 0.2744 0.6521 0.0729 0.3590 100.0000
RTK
 3.1081 9.5863 41.5350 -0.8964 -0.5790 0.0773 -0.9977 -0.7593 -0.1604 0.8453 1.9341 3.1638 0.1417 0.2889 0.4203 5.0593 10.7139 41.5104
nRTK
 5.4804 22.2337 100.0000 -0.9379 -0.5230 0.7469 -0.9624 -0.5665 0.7471 0.4796 1.8144 2.9089 0.0902 0.3724 0.4630 5.1664 30.1168 100.0000
AURK
 1.0819 4.8714 15.7539 -0.6273 -0.3254 0.2416 -1.0000 -0.9899 0.0440 0.5620 0.9422 1.9942 0.1690 0.2734 0.3635 1.8949 8.4549 23.1873
CDK
 0.5707 7.9654 29.9425 -0.8845 -0.5451 0.0597 -0.9797 -0.6968 -0.0854 1.4844 2.5000 3.4868 0.1302 0.2621 0.5141 0.8612 9.5694 29.9503
DNA cross-linker
 4.8692 13.6194 46.5046 -0.9032 -0.7605 -0.5532 -1.0000 -0.9012 -0.5864 0.7951 1.2420 1.9482 0.2973 0.4008 0.5454 16.0331 34.7127 78.9081
TOP
 0.2545 1.3807 12.9467 -0.8258 -0.4563 0.0859 -0.8223 -0.6052 -0.0844 0.5952 1.0576 1.7176 0.2335 0.4645 0.7005 0.4396 1.5669 13.9194
TUBB
 0.0053 0.0099 0.0259 -0.9094 -0.6935 -0.1142 -0.7747 -0.4509 -0.0663 1.0389 1.6781 2.9167 0.5832 0.7368 0.9558 0.0074 0.0127 0.0806
TYMS
 52.7352 100.0000 100.0000 -0.2523 0.0333 0.5457 -0.5776 -0.0792 0.5853 0.3732 0.5600 0.8449 0.2284 0.3186 0.4666 49.7501 100.0000 100.0000
Proteasome
 0.0552 0.1951 0.9914 -0.8677 -0.7659 -0.5358 -0.8745 -0.7563 -0.5161 1.3555 2.0805 3.3776 0.5281 0.7255 0.9392 0.0933 0.2700 1.4071
  • 15 records