Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
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| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SB-3CT | MMP2/9 | MMP | 69.9094 | 100.0000 | 100.0000 | 0.4441 | 0.6795 | 0.8316 | -0.1049 | 0.6210 | 0.7846 | 0.0670 | 0.6905 | 2.4960 | 0.0290 | 0.0754 | 0.1306 | 27.8608 | 93.1362 | 100.0000 | |
| Everolimus | MTOR | MTOR | 0.0432 | 0.6717 | 4.3873 | -0.8294 | -0.6714 | -0.2303 | -1.0000 | -1.0000 | -0.6838 | 0.2890 | 0.4230 | 0.7677 | 0.3295 | 0.4415 | 0.5925 | 1.5205 | 9.7227 | 26.2255 | |
| Sirolimus | MTOR | MTOR | 0.0785 | 2.7199 | 100.0000 | -0.0907 | 0.1172 | 0.3521 | -0.3854 | 0.0690 | 0.4042 | 0.2746 | 0.5743 | 1.0909 | 0.2471 | 0.4095 | 0.5054 | 0.0261 | 0.5698 | 12.7823 | |
| Temsirolimus | MTOR | MTOR | 0.1192 | 1.7003 | 10.0307 | -0.9332 | -0.8176 | -0.6679 | -1.0000 | -1.0000 | -0.9967 | 0.2520 | 0.4363 | 1.0813 | 0.3951 | 0.4933 | 0.6311 | 6.4751 | 18.8586 | 43.0334 | |
| Torkinib | MTOR | MTOR | 0.0008 | 0.0021 | 0.0184 | -0.5713 | -0.3826 | -0.2014 | -0.6715 | -0.4047 | -0.1504 | 0.3324 | 0.3720 | 0.5454 | 0.6694 | 0.8411 | 1.0104 | 0.0046 | 0.0211 | 0.0646 | |
| IKK16 | IKK | NFKB | 1.8767 | 3.1049 | 3.8519 | -0.9668 | -0.9445 | -0.8619 | -0.9890 | -0.9578 | -0.8641 | 2.2018 | 3.4729 | 4.3592 | 0.3739 | 0.4332 | 0.4763 | 3.1521 | 4.0389 | 4.8853 | |
| PS-1145 | IKK | NFKB | 100.0000 | 100.0000 | 100.0000 | 0.8452 | 0.9304 | 0.9718 | 0.8353 | 0.9304 | 0.9695 | 0.0000 | 0.0000 | 0.8067 | -0.0033 | 0.0200 | 0.0533 | 100.0000 | 100.0000 | 100.0000 | |
| TPCA-1 | IKK | NFKB | 4.9121 | 23.5816 | 100.0000 | 0.0988 | 0.4346 | 0.6277 | -0.1071 | 0.3912 | 0.5674 | 0.5796 | 1.2158 | 2.2892 | 0.0966 | 0.1616 | 0.2244 | 2.5700 | 5.7466 | 43.2238 | |
| Dichloroacetate | PDK | PDK | 100.0000 | 100.0000 | 100.0000 | 0.8082 | 0.8801 | 0.9216 | 0.7946 | 0.8670 | 0.9296 | 0.0000 | 0.0000 | 0.2064 | 0.0234 | 0.0440 | 0.0744 | 58.3872 | 100.0000 | 100.0000 | |
| AS-252424 | PI3K | PI3K | 19.5544 | 36.2256 | 100.0000 | 0.2865 | 0.4240 | 0.5918 | -0.9991 | 0.2157 | 0.5619 | 0.3148 | 0.6846 | 2.7243 | 0.0770 | 0.1059 | 0.1601 | 6.6689 | 89.5846 | 100.0000 | |
| Dactolisib | PI3K | PI3K | 0.1885 | 0.5181 | 100.0000 | 0.2549 | 0.5042 | 0.6208 | 0.2262 | 0.4314 | 0.5885 | 0.0000 | 2.2633 | 4.9147 | 0.2133 | 0.2744 | 0.3494 | 0.1148 | 0.3521 | 100.0000 | |
| Omipalisib | PI3K | PI3K | 0.0049 | 0.0154 | 0.0397 | -0.8281 | -0.5752 | -0.4164 | -0.8004 | -0.5070 | -0.2908 | 0.6200 | 0.7592 | 0.9464 | 0.6332 | 0.8101 | 0.9689 | 0.0158 | 0.0370 | 0.0945 | |
| TCS PIM-1 1 | Pim kinase | PIM | 90.9415 | 100.0000 | 100.0000 | 0.4852 | 0.6734 | 0.7827 | 0.3505 | 0.5918 | 0.7255 | 0.0000 | 1.5057 | 4.5238 | 0.0404 | 0.0756 | 0.1063 | 26.3980 | 73.0639 | 100.0000 | |
| PD173074 | FGFR1/3 | RTK | 7.0478 | 8.9285 | 13.6750 | -0.8719 | -0.6669 | -0.2130 | -1.0000 | -0.9488 | -0.5559 | 1.6563 | 2.2671 | 4.5022 | 0.0991 | 0.1926 | 0.2504 | 8.7381 | 13.6708 | 21.0369 | |
| Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.2491 | 0.7096 | 1.5478 | -0.9565 | -0.8762 | -0.7290 | -1.0000 | -1.0000 | -0.9202 | 0.6212 | 0.8572 | 1.4388 | 0.3615 | 0.4228 | 0.5481 | 1.3258 | 2.5025 | 5.3389 | |
| AG1024 | IGF1R | RTK | 14.2327 | 62.8199 | 100.0000 | 0.3069 | 0.5828 | 0.8614 | -0.0340 | 0.2904 | 0.6353 | 0.3280 | 1.4424 | 3.0172 | 0.0186 | 0.0785 | 0.1208 | 8.3409 | 30.1991 | 100.0000 | |
| GSK1838705A | IGF1R | RTK | 4.0665 | 10.9435 | 23.1329 | -0.6969 | -0.3849 | -0.1067 | -0.7773 | -0.4275 | -0.2150 | 1.5275 | 2.6721 | 3.2208 | 0.2264 | 0.2964 | 0.4149 | 2.6121 | 7.6760 | 17.5013 | |
| Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 36.5873 | 68.4588 | 100.0000 | -0.7737 | -0.2023 | 0.2203 | -0.7439 | -0.3900 | 0.2345 | 0.6570 | 1.9429 | 3.4993 | 0.1339 | 0.2188 | 0.2978 | 54.8881 | 71.4700 | 100.0000 | |
| Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 4.8478 | 6.2817 | 9.9436 | -0.9902 | -0.9623 | -0.8818 | -0.9966 | -0.9683 | -0.8864 | 1.4527 | 2.4005 | 3.5359 | 0.3679 | 0.4354 | 0.4695 | 8.0047 | 9.6271 | 12.8243 | |
| Nilotinib | ABL | nRTK | 100.0000 | 100.0000 | 100.0000 | 0.7849 | 0.9109 | 1.0055 | 0.7841 | 0.9109 | 1.0055 | 0.0000 | 0.0000 | 0.7234 | 0.0029 | 0.0487 | 0.0775 | 73.6076 | 100.0000 | 100.0000 | |
| Imatinib | ABL/KIT/PDGFR | nRTK | 18.5481 | 21.7914 | 25.5570 | -0.9852 | -0.9632 | -0.8948 | -0.9969 | -0.9814 | -0.8936 | 2.2328 | 2.7060 | 3.3541 | 0.3997 | 0.4467 | 0.4851 | 27.9144 | 31.9309 | 36.9254 | |
| Bosutinib | Src | nRTK | 1.2187 | 1.7497 | 4.1420 | -0.6727 | -0.4219 | -0.1512 | -0.7662 | -0.4684 | -0.1288 | 0.9612 | 1.6575 | 1.9534 | 0.3079 | 0.3819 | 0.4639 | 1.7722 | 2.5602 | 5.3523 | |
| GSK1070916 | AURK | AURK | 0.6046 | 3.0981 | 6.6549 | -0.8474 | -0.6391 | -0.3610 | -1.0000 | -1.0000 | -0.9999 | 0.6499 | 0.9902 | 1.5949 | 0.2113 | 0.2924 | 0.4314 | 3.5405 | 8.2453 | 15.6107 | |
| ZM-447439 | AURK | AURK | 3.5193 | 19.1991 | 100.0000 | -0.0403 | 0.4141 | 0.5578 | -0.1176 | 0.3301 | 0.5652 | 0.5578 | 1.0337 | 2.9596 | 0.1428 | 0.2012 | 0.3024 | 0.6732 | 2.5837 | 16.4745 | |
| Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.9523 | 4.3787 | 11.8540 | -0.5661 | -0.3376 | -0.0359 | -1.0000 | -1.0000 | -0.4350 | 0.4858 | 0.8218 | 1.3502 | 0.1794 | 0.3014 | 0.3656 | 4.7346 | 16.5294 | 34.8041 |