Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
5-FU
TYMS
TYMS
 43.5628 98.8715 100.0000 -0.6126 -0.4736 -0.0711 -0.8532 -0.6532 -0.1200 0.5225 0.5967 0.7832 0.3295 0.4853 0.6100 100.0000 100.0000 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
Baicalein
Lipoxygenase
Metabolism
 41.6425 70.6950 100.0000 -0.0508 0.2583 0.5386 -0.5772 0.0203 0.4255 1.6411 2.5826 3.9209 0.0595 0.1090 0.1450 32.6213 62.3319 100.0000
Bortezomib
Proteasome
Proteasome
 0.0169 0.0283 0.0758 -0.9074 -0.8026 -0.7299 -0.9162 -0.8011 -0.7357 1.1703 1.8347 2.7508 0.9093 1.0406 1.1781 0.0266 0.0496 0.1485
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
MG-132
Proteasome
Proteasome
 0.1071 0.1768 0.5078 -0.8632 -0.7505 -0.5413 -0.8499 -0.6667 -0.5123 1.5044 2.4128 3.5768 0.6530 0.7329 0.8677 0.1559 0.2469 1.0059
Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
 0.4036 0.5478 1.0248 -0.8567 -0.7928 -0.6682 -0.8570 -0.7958 -0.6543 1.7769 2.1873 3.5139 0.5265 0.6392 0.6811 0.6073 0.7378 1.6091
(Z)-4-Hydroxytamoxifen
ESR1
N/A
 38.2142 72.1652 100.0000 -0.2149 0.3051 0.6418 -0.8145 -0.0997 0.5442 0.6236 1.8012 2.9451 0.0928 0.1395 0.2253 17.7725 43.7586 100.0000
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
CGC-11047
Polyamine analogue
N/A
 43.1451 85.4630 100.0000 -0.8722 -0.7234 -0.2437 -1.0000 -0.9172 -0.4365 0.4134 0.5735 1.1488 0.3172 0.3971 0.4905 94.6485 100.0000 100.0000
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
Nelfinavir
N/A
N/A
 8.4034 9.7440 15.4339 -0.8211 -0.6445 -0.2989 -1.0000 -1.0000 -0.8006 1.6805 2.3548 2.7767 0.1130 0.1589 0.1970 12.4011 15.3815 22.7642
Ribavirin
N/A
N/A
 100.0000 100.0000 100.0000 0.6045 0.7146 0.9546 0.4725 0.6701 0.9546 0.0000 0.0000 0.9838 0.0119 0.0416 0.0703 50.4745 100.0000 100.0000