Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7849.017 | 0.5664 | -0.6112 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7849.017 | 0.3437 | -0.9078 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7849.017 | 0.1589 | -0.9900 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7849.017 | 0.0010 | -1.0000 | 0.3471 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7853.017 | 1.0132 | 1.0151 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7853.017 | 0.9785 | 0.9751 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 0.011 | uM | 7853.017 | 0.9914 | 0.9901 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7853.017 | 1.0328 | 1.0375 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 0.276 | uM | 7853.017 | 0.8945 | 0.8757 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 1.38 | uM | 7853.017 | 0.2406 | -0.1191 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 6.9 | uM | 7853.017 | 0.0371 | -0.6995 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 34.5 | uM | 7853.017 | 0.0630 | -0.5925 | 1.7375 | |
| HCC3153 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 172 | uM | 7853.017 | 0.0015 | -0.9521 | 1.7375 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7854.017 | 0.9775 | 0.9655 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7854.017 | 0.9283 | 0.8896 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 7854.017 | 1.0332 | 1.0504 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7854.017 | 0.6647 | 0.4644 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.276 | uM | 7854.017 | 0.1444 | -0.5434 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 1.38 | uM | 7854.017 | 0.0860 | -0.6925 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 6.9 | uM | 7854.017 | 0.0769 | -0.7176 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 34.5 | uM | 7854.017 | 0.0179 | -0.9071 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7854.017 | 0.0008 | -0.9916 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 9453.017 | 1.0144 | 1.0235 | 1.2279 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 9453.017 | 0.9854 | 0.9761 | 1.2279 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 9453.017 | 0.9956 | 0.9928 | 1.2279 |