Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7798.017 | 0.6859 | 0.5325 | 1.4161 | |
| BT-474 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7798.017 | 0.9311 | 0.9017 | 1.4161 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7801.035 | 0.9657 | 0.8755 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7801.035 | 0.9813 | 0.9315 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7801.035 | 0.9304 | 0.7509 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7801.035 | 1.0069 | 1.0255 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7801.035 | 0.7832 | 0.2750 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7801.035 | 0.5522 | -0.3305 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7801.035 | 0.5224 | -0.3954 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7801.035 | 0.6037 | -0.2109 | 0.5427 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7801.035 | 0.0054 | -0.9999 | 0.5427 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7803.017 | 0.9494 | 0.9652 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7803.017 | 1.0093 | 1.0063 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 7803.017 | 0.7800 | 0.8388 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7803.017 | 0.8770 | 0.9132 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.276 | uM | 7803.017 | 0.3371 | 0.3846 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 1.38 | uM | 7803.017 | 0.0290 | -0.3961 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 6.9 | uM | 7803.017 | 0.0083 | -0.6042 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 34.5 | uM | 7803.017 | 0.0066 | -0.6337 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7803.017 | 0.0002 | -0.8801 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7804.017 | 0.9895 | 0.9919 | 2.5963 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7804.017 | 0.9789 | 0.9836 | 2.5963 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 7804.017 | 0.9935 | 0.9950 | 2.5963 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7804.017 | 0.9491 | 0.9602 | 2.5963 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 0.276 | uM | 7804.017 | 0.5020 | 0.5337 | 2.5963 |