Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7907.037 | 1.0898 | 1.1298 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7907.037 | 1.1144 | 1.1648 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7907.037 | 0.9323 | 0.9001 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7907.037 | 0.1942 | -0.3968 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7907.037 | 0.2500 | -0.2744 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7907.037 | 0.0536 | -0.7647 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7909.05 | 1.0338 | 1.0590 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7909.05 | 1.4198 | 1.7179 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7909.05 | 0.8744 | 0.7785 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7909.05 | 1.2278 | 1.3933 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7909.05 | 1.3566 | 1.6116 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7909.05 | 1.1508 | 1.2616 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7909.05 | 0.4093 | -0.0846 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7909.05 | 0.3521 | -0.1977 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7909.05 | 0.1156 | -0.6971 | 1.1429 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7912.05 | 0.9829 | 0.9303 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7912.05 | 0.9564 | 0.8248 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7912.05 | 0.9419 | 0.7682 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7912.05 | 0.6399 | -0.2016 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7912.05 | 0.4840 | -0.5504 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7912.05 | 0.4836 | -0.5511 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7912.05 | 0.4959 | -0.5273 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7912.05 | 0.4391 | -0.6320 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7912.05 | 0.1879 | -0.9357 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9759.037 | 1.0354 | 1.0544 | 1.2944 |