Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9723.037 | 0.2074 | -0.5626 | 1.0349 | |
| MDA-MB-453 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9723.037 | 0.1963 | -0.5852 | 1.0349 | |
| MDA-MB-453 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9723.037 | 0.2192 | -0.5386 | 1.0349 | |
| MDA-MB-453 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9723.037 | 0.0204 | -0.9535 | 1.0349 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7905.037 | 1.0005 | 1.0015 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7905.037 | 0.9384 | 0.8193 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7905.037 | 0.9385 | 0.8196 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7905.037 | 1.0943 | 1.2872 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7905.037 | 1.0492 | 1.1482 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7905.037 | 0.8733 | 0.6344 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7905.037 | 0.1512 | -0.8801 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7905.037 | 0.3700 | -0.5453 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7905.037 | 0.0139 | -0.9966 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7906.037 | 0.5656 | -0.0214 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7906.037 | 1.1418 | 1.3619 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7906.037 | 0.5793 | 0.0084 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7906.037 | 0.8622 | 0.6607 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7906.037 | 0.9961 | 0.9901 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7906.037 | 0.7740 | 0.4503 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7906.037 | 0.2707 | -0.6118 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7906.037 | 0.1624 | -0.7954 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7906.037 | 0.0390 | -0.9658 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7907.037 | 0.9285 | 0.8944 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7907.037 | 1.1996 | 1.2847 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7907.037 | 0.8832 | 0.8264 | 1.3673 |