Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 12714.174 | 0.9535 | 0.7318 | 0.3306 | |
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 12714.174 | 0.9201 | 0.5546 | 0.3306 | |
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 12714.174 | 0.9816 | 0.8907 | 0.3306 | |
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 12714.174 | 1.0370 | 1.2320 | 0.3306 | |
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 12714.174 | 1.0035 | 1.0210 | 0.3306 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 12622.174 | 0.9992 | 0.9994 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 12622.174 | 0.9935 | 0.9947 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 12622.174 | 1.0083 | 1.0068 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 12622.174 | 1.0083 | 1.0068 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 12622.174 | 0.9390 | 0.9490 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 12622.174 | 0.6444 | 0.6699 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 12622.174 | 0.8104 | 0.8346 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 12622.174 | 0.2802 | 0.1863 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 12622.174 | 0.0025 | -0.8300 | 2.4358 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 12627.174 | 0.9710 | 0.9567 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 12627.174 | 0.9785 | 0.9679 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.00427 | uM | 12627.174 | 0.9863 | 0.9795 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.0213 | uM | 12627.174 | 1.0229 | 1.0340 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 12627.174 | 0.6933 | 0.5223 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 12627.174 | 0.5967 | 0.3612 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 2.67 | uM | 12627.174 | 0.9152 | 0.8721 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13.3 | uM | 12627.174 | 0.1702 | -0.4654 | 1.3419 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 66.7 | uM | 12627.174 | 0.0085 | -0.9429 | 1.3419 | |
| MCF 10A | NM | Basal B | Disulfiram | Proteasome | Proteasome | 0.000171 | uM | 12944.174 | 0.9672 | 0.9763 | 2.7985 | |
| MCF 10A | NM | Basal B | Disulfiram | Proteasome | Proteasome | 0.000853 | uM | 12944.174 | 1.0416 | 1.0293 | 2.7985 |