Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 7870.007 | 0.3471 | 0.1999 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 7870.007 | 0.1102 | -0.3107 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9551.121 | 1.0450 | 1.0324 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9551.121 | 1.0240 | 1.0174 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9551.121 | 1.0197 | 1.0143 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9551.121 | 1.0087 | 1.0063 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 9551.121 | 0.9397 | 0.9551 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 9551.121 | 0.6738 | 0.7318 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 9551.121 | 0.4802 | 0.5305 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 9551.121 | 0.3172 | 0.3157 | 2.7416 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 9551.121 | 0.1483 | -0.0029 | 2.7416 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7488.078 | 0.9612 | 0.9484 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7488.078 | 0.9350 | 0.9131 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7488.078 | 0.7908 | 0.7126 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7488.078 | 0.9684 | 0.9580 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.136 | uM | 7488.078 | 0.9085 | 0.8770 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.682 | uM | 7488.078 | 0.7985 | 0.7236 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 3.41 | uM | 7488.078 | 0.7842 | 0.7032 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 17.1 | uM | 7488.078 | 0.5341 | 0.3214 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 85.2 | uM | 7488.078 | 0.3886 | 0.0707 | 1.5130 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7872.007 | 0.9508 | 0.9420 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7872.007 | 1.0051 | 1.0060 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7872.007 | 1.4125 | 1.4468 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7872.007 | 0.9652 | 0.9590 | 1.7126 | |
| MCF 10F | NM | - | CPT-11 | TOP1 | TOP | 0.118 | uM | 7872.007 | 0.9731 | 0.9683 | 1.7126 |