Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Perturbagen Concentration Perturbagen Conc Unit Biological Replicate ID Relative Cell Count Normalized Growth Rate Inhibition Value Nominal Division Rate
LY2
HR+
Luminal
CPT-11
TOP1
TOP
0.000218
uM
10264.121
0.9753 0.9636 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
0.00109
uM
10264.121
0.9892 0.9841 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
0.00546
uM
10264.121
0.9897 0.9849 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
0.0273
uM
10264.121
0.9494 0.9253 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
0.136
uM
10264.121
0.9419 0.9142 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
0.682
uM
10264.121
0.9112 0.8683 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
3.41
uM
10264.121
0.8201 0.7295 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
17.1
uM
10264.121
0.6833 0.5129 1.3643
LY2
HR+
Luminal
CPT-11
TOP1
TOP
85.2
uM
10264.121
0.1524 -0.4963 1.3643
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
0.000218
uM
9039.078
1.0096 1.0306 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
0.00109
uM
9039.078
0.9792 0.9345 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
0.00546
uM
9039.078
1.0162 1.0517 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
0.0273
uM
9039.078
1.0235 1.0750 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
0.136
uM
9039.078
1.0117 1.0374 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
0.682
uM
9039.078
0.9307 0.7847 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
3.41
uM
9039.078
0.8524 0.5526 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
17.1
uM
9039.078
0.3527 -0.6169 0.6306
MB 157
Unknown
Unknown
CPT-11
TOP1
TOP
85.2
uM
9039.078
0.0408 -0.9875 0.6306
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
0.000189
uM
7870.007
0.8813 0.8816 2.0710
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
0.000945
uM
7870.007
0.9835 0.9840 2.0710
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
0.00472
uM
7870.007
1.0458 1.0437 2.0710
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
0.0236
uM
7870.007
0.9518 0.9528 2.0710
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
0.118
uM
7870.007
0.8970 0.8977 2.0710
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
0.59
uM
7870.007
0.7055 0.6900 2.0710
MCF 10A
NM
Basal B
CPT-11
TOP1
TOP
2.95
uM
7870.007
0.5403 0.4857 2.0710