Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10264.121 | 0.9753 | 0.9636 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10264.121 | 0.9892 | 0.9841 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10264.121 | 0.9897 | 0.9849 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10264.121 | 0.9494 | 0.9253 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 10264.121 | 0.9419 | 0.9142 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 10264.121 | 0.9112 | 0.8683 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 10264.121 | 0.8201 | 0.7295 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 10264.121 | 0.6833 | 0.5129 | 1.3643 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10264.121 | 0.1524 | -0.4963 | 1.3643 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9039.078 | 1.0096 | 1.0306 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9039.078 | 0.9792 | 0.9345 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9039.078 | 1.0162 | 1.0517 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9039.078 | 1.0235 | 1.0750 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.136 | uM | 9039.078 | 1.0117 | 1.0374 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.682 | uM | 9039.078 | 0.9307 | 0.7847 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 3.41 | uM | 9039.078 | 0.8524 | 0.5526 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 17.1 | uM | 9039.078 | 0.3527 | -0.6169 | 0.6306 | |
| MB 157 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 85.2 | uM | 9039.078 | 0.0408 | -0.9875 | 0.6306 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7870.007 | 0.8813 | 0.8816 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7870.007 | 0.9835 | 0.9840 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7870.007 | 1.0458 | 1.0437 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7870.007 | 0.9518 | 0.9528 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 7870.007 | 0.8970 | 0.8977 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 7870.007 | 0.7055 | 0.6900 | 2.0710 | |
| MCF 10A | NM | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 7870.007 | 0.5403 | 0.4857 | 2.0710 |