Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 9258.121 | 0.9731 | 0.8896 | 0.4800 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 9258.121 | 0.9095 | 0.6413 | 0.4800 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 9258.121 | 0.5638 | -0.3940 | 0.4800 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 9258.121 | 0.4122 | -0.6843 | 0.4800 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 9258.121 | 0.0596 | -0.9944 | 0.4800 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7820.007 | 1.0136 | 1.0398 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7820.007 | 1.0882 | 1.2631 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7820.007 | 1.0591 | 1.1753 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7820.007 | 1.0563 | 1.1668 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7820.007 | 1.0254 | 1.0747 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7820.007 | 1.0825 | 1.2457 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7820.007 | 1.0090 | 1.0264 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7820.007 | 0.9475 | 0.8483 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7820.007 | 0.3895 | -0.4963 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7821.007 | 0.9736 | 0.9233 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7821.007 | 0.8986 | 0.7104 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7821.007 | 0.9254 | 0.7856 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7821.007 | 0.9618 | 0.8894 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7821.007 | 0.9507 | 0.8574 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7821.007 | 0.9473 | 0.8478 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7821.007 | 0.9110 | 0.7451 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7821.007 | 0.7743 | 0.3757 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7821.007 | 0.4213 | -0.4350 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9278.121 | 1.0061 | 1.0271 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9278.121 | 1.0194 | 1.0874 | 0.4498 |