Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7857.05 | 0.4321 | 0.0236 | 1.2527 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7857.05 | 0.2987 | -0.2378 | 1.2527 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7857.05 | 0.2559 | -0.3262 | 1.2527 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7857.05 | 0.0825 | -0.7270 | 1.2527 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7860.04 | 1.0467 | 1.1348 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7860.04 | 0.9738 | 0.9256 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7860.04 | 1.0564 | 1.1630 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7860.04 | 1.0318 | 1.0914 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7860.04 | 0.9522 | 0.8648 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7860.04 | 0.5922 | -0.0536 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7860.04 | 0.4013 | -0.4570 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7860.04 | 0.3418 | -0.5682 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7860.04 | 0.0955 | -0.9301 | 0.7003 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9501.037 | 1.0259 | 1.0518 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9501.037 | 1.0658 | 1.1317 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9501.037 | 1.0131 | 1.0262 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9501.037 | 1.0331 | 1.0661 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9501.037 | 0.5523 | 0.1045 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9501.037 | 0.3332 | -0.3338 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 9501.037 | 0.2546 | -0.4910 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 9501.037 | 0.1899 | -0.6203 | 0.9998 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 9501.037 | 0.0643 | -0.8715 | 0.9998 | |
| HMT-3522 S1 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7911.05 | 1.0153 | 1.0170 | 1.7938 | |
| HMT-3522 S1 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7911.05 | 1.0617 | 1.0679 | 1.7938 | |
| HMT-3522 S1 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7911.05 | 1.0218 | 1.0242 | 1.7938 |