Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 1.6 | uM | 7871.018 | 0.8163 | 0.6881 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 8 | uM | 7871.018 | 0.6576 | 0.4093 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 40 | uM | 7871.018 | 0.7692 | 0.6065 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 200 | uM | 7871.018 | 0.7081 | 0.4991 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 1000 | uM | 7871.018 | 0.3045 | -0.2592 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 5000 | uM | 7871.018 | 0.0148 | -0.9407 | 1.1973 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9566.026 | 1.0315 | 1.0293 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 0.064 | uM | 9566.026 | 0.8735 | 0.8774 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 0.32 | uM | 9566.026 | 0.7584 | 0.7572 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 1.6 | uM | 9566.026 | 0.7021 | 0.6949 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 8 | uM | 9566.026 | 0.6920 | 0.6835 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 40 | uM | 9566.026 | 0.9740 | 0.9755 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 200 | uM | 9566.026 | 0.8929 | 0.8967 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 1000 | uM | 9566.026 | 0.2221 | -0.0110 | 2.1367 | ||
| MCF 10F | NM | - | CGC-11047 | Polyamine analogue | 5000 | uM | 9566.026 | 0.0070 | -0.8038 | 2.1367 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 0.000256 | uM | 10061.123 | 1.0905 | 1.0930 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 0.00128 | uM | 10061.123 | 0.9406 | 0.9368 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 0.0064 | uM | 10061.123 | 1.0560 | 1.0580 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 0.032 | uM | 10061.123 | 0.9717 | 0.9701 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 0.16 | uM | 10061.123 | 1.0113 | 1.0118 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 0.8 | uM | 10061.123 | 0.8077 | 0.7880 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 4 | uM | 10061.123 | 0.7971 | 0.7756 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 20 | uM | 10061.123 | 0.6879 | 0.6436 | 1.9064 | ||
| MCF12A | NM | Basal B | CGC-11047 | Polyamine analogue | 100 | uM | 10061.123 | 0.6491 | 0.5944 | 1.9064 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7874.018 | 1.0336 | 1.0405 | 1.6506 |