Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9163.026 | 0.2639 | -0.9433 | 0.3738 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9163.026 | 0.0078 | -1.0000 | 0.3738 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7801.018 | 0.9950 | 0.9833 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7801.018 | 0.9561 | 0.8536 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7801.018 | 0.9556 | 0.8523 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7801.018 | 0.8799 | 0.6109 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7801.018 | 1.1217 | 1.4287 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7801.018 | 0.9482 | 0.8278 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7801.018 | 0.8597 | 0.5488 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7801.018 | 0.6712 | 0.0189 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7801.018 | 0.3650 | -0.6364 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9186.026 | 1.1179 | 1.4876 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 9186.026 | 1.0402 | 1.1606 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9186.026 | 1.0850 | 1.3462 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9186.026 | 1.0150 | 1.0592 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9186.026 | 1.0074 | 1.0291 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9186.026 | 1.0176 | 1.0697 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9186.026 | 0.9923 | 0.9701 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9186.026 | 0.8233 | 0.3670 | 0.5108 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9186.026 | 0.5237 | -0.4363 | 0.5108 | ||
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9024.018 | 0.9153 | 0.9384 | 2.8306 | ||
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 9024.018 | 0.9606 | 0.9718 | 2.8306 | ||
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 9024.018 | 0.6942 | 0.7580 | 2.8306 | ||
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 9024.018 | 0.6239 | 0.6929 | 2.8306 | ||
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 9024.018 | 0.6147 | 0.6841 | 2.8306 |