Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 10095.021 | 0.7194 | 0.3962 | 0.9164 | |
| MDA-MB-361 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 10095.021 | 0.2760 | -0.5091 | 0.9164 | |
| MDA-MB-361 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 10095.021 | 0.2616 | -0.5371 | 0.9164 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7897.011 | 0.9728 | 0.9180 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7897.011 | 0.9699 | 0.9093 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7897.011 | 1.0144 | 1.0438 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7897.011 | 0.9849 | 0.9545 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7897.011 | 1.0043 | 1.0130 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7897.011 | 0.9834 | 0.9498 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7897.011 | 0.9942 | 0.9824 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7897.011 | 0.8223 | 0.4863 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7897.011 | 0.2426 | -0.7668 | 0.6591 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9664.12 | 1.0300 | 1.1132 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9664.12 | 0.9674 | 0.8803 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9664.12 | 1.0912 | 1.3531 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9664.12 | 0.9605 | 0.8554 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9664.12 | 0.9555 | 0.8372 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9664.12 | 1.0323 | 1.1221 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9664.12 | 0.9098 | 0.6771 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9664.12 | 0.5891 | -0.2537 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9664.12 | 0.0818 | -0.9811 | 0.5368 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7898.011 | 1.0040 | 1.0077 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7898.011 | 1.0768 | 1.1478 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7898.011 | 0.9981 | 0.9963 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7898.011 | 1.0221 | 1.0426 | 1.0373 |