Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9186.119 | 0.7326 | 0.0379 | 0.4743 | |
| BT-483 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9186.119 | 0.7427 | 0.0681 | 0.4743 | |
| BT-483 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9186.119 | 0.5841 | -0.3563 | 0.4743 | |
| BT-483 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9186.119 | 0.4145 | -0.6877 | 0.4743 | |
| BT-483 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9186.119 | 0.3225 | -0.8160 | 0.4743 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7803.011 | 1.0326 | 1.0214 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7803.011 | 1.0285 | 1.0188 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7803.011 | 1.0105 | 1.0069 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7803.011 | 1.0152 | 1.0100 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7803.011 | 0.9933 | 0.9955 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7803.011 | 0.7903 | 0.8496 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7803.011 | 0.2082 | 0.1872 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7803.011 | 0.0059 | -0.6366 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7803.011 | 0.0072 | -0.6127 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7804.011 | 1.0101 | 1.0084 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7804.011 | 1.0273 | 1.0225 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7804.011 | 1.0009 | 1.0008 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7804.011 | 1.0508 | 1.0416 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7804.011 | 1.0180 | 1.0149 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7804.011 | 0.8934 | 0.9086 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7804.011 | 0.4302 | 0.4097 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7804.011 | 0.0173 | -0.6279 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7804.011 | 0.0096 | -0.7090 | 2.4113 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9024.075 | 0.9562 | 0.9693 | 2.8935 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9024.075 | 1.0734 | 1.0496 | 2.8935 |