Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10818.145 | 0.8770 | 0.5056 | 0.4621 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10818.145 | 0.6264 | -0.2733 | 0.4621 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10818.145 | 0.4321 | -0.6746 | 0.4621 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10818.145 | 0.4811 | -0.5893 | 0.4621 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 12126.145 | 0.9208 | 0.7612 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 12126.145 | 0.9236 | 0.7696 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 12126.145 | 0.9746 | 0.9222 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 12126.145 | 0.9540 | 0.8600 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 12126.145 | 0.9813 | 0.9426 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 12126.145 | 0.8473 | 0.5496 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 12126.145 | 0.4898 | -0.3338 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 12126.145 | 0.3204 | -0.6535 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 12126.145 | 0.2639 | -0.7430 | 0.6493 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10643.145 | 1.0107 | 1.0495 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10643.145 | 1.0212 | 1.0986 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10643.145 | 0.9835 | 0.9249 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 10643.145 | 0.9914 | 0.9605 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 10643.145 | 1.0383 | 1.1805 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10643.145 | 0.8869 | 0.5183 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10643.145 | 0.6812 | -0.1715 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10643.145 | 0.5133 | -0.5675 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10643.145 | 0.4572 | -0.6683 | 0.4356 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10999.145 | 0.9146 | 0.7788 | 0.7621 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10999.145 | 0.9587 | 0.8924 | 0.7621 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10999.145 | 0.9714 | 0.9253 | 0.7621 |