Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 15332.203 | 0.0106 | -0.9967 | 0.7106 | |
| SUM185PE | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15332.203 | 0.0117 | -0.9962 | 0.7106 | |
| SUM185PE | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15332.203 | 0.0117 | -0.9962 | 0.7106 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7533.074 | 1.0722 | 1.1352 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7533.074 | 1.0722 | 1.1352 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7533.074 | 1.0282 | 1.0529 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7533.074 | 1.0282 | 1.0529 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 7533.074 | 1.0264 | 1.0496 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 7533.074 | 1.0264 | 1.0496 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.0533 | uM | 7533.074 | 0.7656 | 0.5563 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.0533 | uM | 7533.074 | 0.7656 | 0.5563 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.267 | uM | 7533.074 | 0.3871 | -0.1798 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.267 | uM | 7533.074 | 0.3871 | -0.1798 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 7533.074 | 0.2527 | -0.4505 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 7533.074 | 0.2527 | -0.4505 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 7533.074 | 0.1840 | -0.5920 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 7533.074 | 0.1840 | -0.5920 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7533.074 | 0.1629 | -0.6362 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7533.074 | 0.1629 | -0.6362 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 167 | uM | 7533.074 | 0.1435 | -0.6770 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 167 | uM | 7533.074 | 0.1435 | -0.6770 | 1.0648 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7534.074 | 1.0136 | 1.0246 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7534.074 | 1.0136 | 1.0246 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7534.074 | 1.0085 | 1.0154 | 1.1026 | |
| SUM225CWN | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7534.074 | 1.0085 | 1.0154 | 1.1026 |