Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 2.67 | uM | 15310.203 | 0.0090 | -0.7033 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 2.67 | uM | 15310.203 | 0.0090 | -0.7033 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 15310.203 | 0.0177 | -0.6099 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 15310.203 | 0.0177 | -0.6099 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15310.203 | 0.0232 | -0.5648 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15310.203 | 0.0232 | -0.5648 | 2.4683 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.000171 | uM | 14743.203 | 0.9541 | 0.9560 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.000171 | uM | 14743.203 | 0.9541 | 0.9560 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.000853 | uM | 14743.203 | 0.9172 | 0.9198 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.000853 | uM | 14743.203 | 0.9172 | 0.9198 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.00427 | uM | 14743.203 | 0.9375 | 0.9398 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.00427 | uM | 14743.203 | 0.9375 | 0.9398 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.0213 | uM | 14743.203 | 0.2209 | -0.0210 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.0213 | uM | 14743.203 | 0.2209 | -0.0210 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.107 | uM | 14743.203 | 0.0186 | -0.6964 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.107 | uM | 14743.203 | 0.0186 | -0.6964 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.533 | uM | 14743.203 | 0.0106 | -0.7672 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 0.533 | uM | 14743.203 | 0.0106 | -0.7672 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 2.67 | uM | 14743.203 | 0.0090 | -0.7842 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 2.67 | uM | 14743.203 | 0.0090 | -0.7842 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 14743.203 | 0.0095 | -0.7785 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 14743.203 | 0.0095 | -0.7785 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 14743.203 | 0.0099 | -0.7748 | 2.1139 | |
| JIMT-1 | HER2amp | Basal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 14743.203 | 0.0099 | -0.7748 | 2.1139 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7477.074 | 1.0829 | 1.2684 | 0.6324 |