Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00213 | uM | 10937.15 | 0.9438 | 0.9177 | 1.3769 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0107 | uM | 10937.15 | 0.9694 | 0.9554 | 1.3769 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0533 | uM | 10937.15 | 0.9895 | 0.9847 | 1.3769 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.267 | uM | 10937.15 | 0.9106 | 0.8685 | 1.3769 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 1.33 | uM | 10937.15 | 0.8513 | 0.7793 | 1.3769 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 6.67 | uM | 10937.15 | 0.8039 | 0.7069 | 1.3769 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 33.3 | uM | 10937.15 | 0.7200 | 0.5754 | 1.3769 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000256 | uM | 10578.138 | 0.9170 | 0.9053 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00128 | uM | 10578.138 | 0.9759 | 0.9729 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0064 | uM | 10578.138 | 0.8764 | 0.8577 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.032 | uM | 10578.138 | 0.9365 | 0.9279 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.16 | uM | 10578.138 | 0.9401 | 0.9321 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.8 | uM | 10578.138 | 0.4626 | 0.2991 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 4 | uM | 10578.138 | 0.4039 | 0.2041 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 20 | uM | 10578.138 | 0.3141 | 0.0459 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 100 | uM | 10578.138 | 0.3882 | 0.1777 | 1.7866 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000256 | uM | 11850.16 | 0.9172 | 0.9101 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00128 | uM | 11850.16 | 0.9522 | 0.9486 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0064 | uM | 11850.16 | 0.9782 | 0.9767 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.032 | uM | 11850.16 | 0.9547 | 0.9513 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.16 | uM | 11850.16 | 0.9585 | 0.9555 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.8 | uM | 11850.16 | 0.2795 | 0.0150 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 4 | uM | 11850.16 | 0.2692 | -0.0050 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 20 | uM | 11850.16 | 0.1613 | -0.2423 | 1.8797 | |
| HCC38 | TNBC | Basal B | ZM-447439 | AURK | AURK | 100 | uM | 11850.16 | 0.1426 | -0.2903 | 1.8797 |