Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 12070.16 | 0.7604 | 0.4465 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 12070.16 | 0.7317 | 0.3822 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 12070.16 | 0.6650 | 0.2343 | 0.8453 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 12070.16 | 0.1212 | -0.8353 | 0.8453 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 12112.16 | 0.9643 | 0.9578 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 12112.16 | 0.9866 | 0.9842 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 12112.16 | 0.9388 | 0.9274 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 12112.16 | 0.9656 | 0.9594 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 12112.16 | 0.9716 | 0.9665 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 12112.16 | 0.6918 | 0.6118 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 12112.16 | 0.6422 | 0.5431 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 12112.16 | 0.5828 | 0.4578 | 1.7073 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 12112.16 | 0.5679 | 0.4358 | 1.7073 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000256 | uM | 10518.138 | 0.8080 | 0.7060 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 10518.138 | 0.9317 | 0.8972 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 10518.138 | 0.9383 | 0.9073 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 10518.138 | 0.9720 | 0.9582 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 10518.138 | 0.9134 | 0.8694 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 10518.138 | 0.4012 | 0.0123 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 10518.138 | 0.4543 | 0.1106 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 10518.138 | 0.4010 | 0.0120 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 10518.138 | 0.4549 | 0.1116 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10753.15 | 0.9454 | 0.9220 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.000427 | uM | 10753.15 | 0.9075 | 0.8671 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.00213 | uM | 10753.15 | 0.9889 | 0.9842 | 1.4129 |