Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14637.189 | 0.0091 | -0.6468 | 2.7087 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14640.189 | 0.9641 | 0.9541 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14640.189 | 0.9428 | 0.9265 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14640.189 | 0.9699 | 0.9615 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14640.189 | 0.9592 | 0.9477 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14640.189 | 0.9684 | 0.9595 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14640.189 | 0.9351 | 0.9164 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14640.189 | 0.4146 | 0.1423 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14640.189 | 0.0363 | -0.7573 | 1.5721 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14640.189 | 0.0235 | -0.8158 | 1.5721 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14264.189 | 0.9393 | 0.9034 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14264.189 | 0.9656 | 0.9454 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14264.189 | 0.9565 | 0.9308 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14264.189 | 0.9563 | 0.9306 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14264.189 | 0.9457 | 0.9136 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14264.189 | 0.8846 | 0.8152 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14264.189 | 0.0217 | -0.9033 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14264.189 | 0.0191 | -0.9127 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14264.189 | 0.0536 | -0.8023 | 1.2647 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14218.189 | 0.9892 | 0.9834 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14218.189 | 0.9167 | 0.8716 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14218.189 | 0.9566 | 0.9334 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14218.189 | 0.9558 | 0.9322 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14218.189 | 0.9653 | 0.9469 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14218.189 | 0.5318 | 0.2355 | 1.3111 |