Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14260.189 | 1.0202 | 1.0253 | 1.5886 | |
| Hs 578T | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14260.189 | 1.0503 | 1.0627 | 1.5886 | |
| Hs 578T | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14260.189 | 0.6526 | 0.5288 | 1.5886 | |
| Hs 578T | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14260.189 | 0.0032 | -0.9458 | 1.5886 | |
| Hs 578T | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14260.189 | 0.0141 | -0.8629 | 1.5886 | |
| Hs 578T | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14260.189 | 0.0010 | -0.9736 | 1.5886 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14134.189 | 0.9774 | 0.9835 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14134.189 | 1.0759 | 1.0538 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14134.189 | 0.9388 | 0.9547 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14134.189 | 1.0488 | 1.0349 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14134.189 | 1.0997 | 1.0702 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14134.189 | 0.9668 | 0.9756 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14134.189 | 0.5219 | 0.5798 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14134.189 | 0.0673 | -0.2486 | 2.7572 | |
| LY2 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14134.189 | 0.0491 | -0.3296 | 2.7572 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14215.189 | 0.9414 | 0.9645 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14215.189 | 0.9320 | 0.9586 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14215.189 | 0.9570 | 0.9740 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14215.189 | 0.9726 | 0.9836 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14215.189 | 0.5556 | 0.6796 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14215.189 | 0.1170 | 0.0571 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14215.189 | 0.0069 | -0.5432 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14215.189 | 0.0127 | -0.4539 | 3.3654 | |
| MCF 10A | NM | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14215.189 | 0.0073 | -0.5358 | 3.3654 | |
| MCF 10F | NM | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14161.189 | 0.9959 | 0.9926 | 1.1003 |