Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7533.065 | 0.9111 | 0.8330 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7533.065 | 0.9065 | 0.8243 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7533.065 | 0.7197 | 0.4699 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7533.065 | 0.2055 | -0.5454 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7533.065 | 0.0562 | -0.8651 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7533.065 | 0.0449 | -0.8907 | 1.0679 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7534.065 | 1.0281 | 1.0590 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7534.065 | 1.0971 | 1.2043 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7534.065 | 1.0090 | 1.0190 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7534.065 | 0.8743 | 0.7370 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7534.065 | 1.0300 | 1.0630 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7534.065 | 0.7638 | 0.5073 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7534.065 | 0.1788 | -0.6716 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7534.065 | 0.0366 | -0.9378 | 0.9529 | |
| SUM225CWN | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7534.065 | 0.0346 | -0.9415 | 0.9529 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 0.048 | uM | 7535.065 | 1.0428 | 1.0991 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 0.24 | uM | 7535.065 | 0.9466 | 0.8771 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 1.2 | uM | 7535.065 | 0.9756 | 0.9437 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 6 | uM | 7535.065 | 1.0486 | 1.1127 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 30 | uM | 7535.065 | 0.8730 | 0.7098 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 150 | uM | 7535.065 | 0.4977 | -0.1062 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 750 | uM | 7535.065 | 0.1755 | -0.7316 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 3750 | uM | 7535.065 | 0.0382 | -0.9538 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 18700 | uM | 7535.065 | 0.0261 | -0.9702 | 0.8663 | |
| SUM229PE | TNBC | - | Vorinostat | HDAC | HDAC | 0.048 | uM | 7537.065 | 1.0021 | 1.0023 | 1.8673 |