Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12269.143 | 0.6337 | -0.5435 | 0.3088 | |
| SUM185PE | TNBC | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12269.143 | 0.2654 | -0.9728 | 0.3088 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10579.143 | 1.1000 | 1.2644 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 10579.143 | 0.9589 | 0.8935 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 10579.143 | 1.0058 | 1.0150 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 10579.143 | 1.0079 | 1.0206 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 10579.143 | 0.9999 | 0.9996 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 10579.143 | 0.9816 | 0.9522 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 10579.143 | 0.9139 | 0.7787 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 10579.143 | 0.6181 | 0.0688 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 10579.143 | 0.0407 | -0.9691 | 0.7678 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12098.143 | 1.0000 | 1.0000 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 12098.143 | 1.1332 | 1.2716 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 12098.143 | 1.0071 | 1.0144 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 12098.143 | 1.1154 | 1.2352 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 12098.143 | 0.8920 | 0.7803 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 12098.143 | 0.9891 | 0.9777 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 12098.143 | 0.9718 | 0.9425 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 12098.143 | 0.5864 | 0.1614 | 0.9820 | |
| SUM225CWN | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 12098.143 | 0.0273 | -0.9490 | 0.9820 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 0.0384 | uM | 11058.143 | 0.9172 | 0.9274 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 0.192 | uM | 11058.143 | 0.9744 | 0.9779 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 0.96 | uM | 11058.143 | 0.9650 | 0.9698 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 4.8 | uM | 11058.143 | 0.9427 | 0.9501 | 2.3374 | |
| SUM229PE | TNBC | - | Valproic acid | HDAC | HDAC | 24 | uM | 11058.143 | 0.9049 | 0.9163 | 2.3374 |