Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10997.143 | 0.9979 | 0.9934 | 0.6416 | |
| MCF7 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10997.143 | 0.9787 | 0.9340 | 0.6416 | |
| MCF7 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10997.143 | 0.7440 | 0.2615 | 0.6416 | |
| MCF7 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10997.143 | 0.2215 | -0.8091 | 0.6416 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10998.143 | 0.9778 | 0.9261 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10998.143 | 0.9624 | 0.8757 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10998.143 | 0.9614 | 0.8724 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10998.143 | 0.9639 | 0.8807 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10998.143 | 0.9699 | 0.9003 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10998.143 | 0.9689 | 0.8970 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10998.143 | 0.8385 | 0.4895 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10998.143 | 0.4541 | -0.4664 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10998.143 | 0.0169 | -0.9978 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12206.143 | 0.9903 | 0.9818 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12206.143 | 1.0222 | 1.0415 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12206.143 | 0.9733 | 0.9498 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12206.143 | 1.0392 | 1.0733 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12206.143 | 0.9134 | 0.8373 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12206.143 | 0.9688 | 0.9415 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12206.143 | 0.7940 | 0.6114 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12206.143 | 0.4249 | -0.1028 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12206.143 | 0.0255 | -0.9356 | 1.0676 | |
| MDA-MB-157 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12594.143 | 1.0817 | 1.1268 | 1.2787 | |
| MDA-MB-157 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 0.192 | uM | 12594.143 | 0.9937 | 0.9901 | 1.2787 | |
| MDA-MB-157 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 0.96 | uM | 12594.143 | 1.0257 | 1.0401 | 1.2787 |