Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 10755.152 | 0.9968 | 0.9891 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 10755.152 | 0.9685 | 0.8936 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10755.152 | 0.9375 | 0.7914 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 10755.152 | 0.7124 | 0.1212 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 10755.152 | 0.2622 | -0.7964 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10755.152 | 0.1434 | -0.9273 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12070.159 | 1.0381 | 1.0775 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12070.159 | 1.0645 | 1.1310 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12070.159 | 1.0105 | 1.0214 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12070.159 | 1.0474 | 1.0963 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12070.159 | 1.0622 | 1.1265 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12070.159 | 0.9116 | 0.8206 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12070.159 | 0.3794 | -0.2526 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12070.159 | 0.0347 | -0.9341 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12070.159 | 0.0215 | -0.9595 | 0.9846 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12112.159 | 0.9759 | 0.9740 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12112.159 | 0.8983 | 0.8880 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12112.159 | 0.9825 | 0.9812 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12112.159 | 1.0648 | 1.0686 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12112.159 | 1.0103 | 1.0110 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12112.159 | 0.6591 | 0.5986 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12112.159 | 0.1700 | -0.2283 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12112.159 | 0.1394 | -0.3064 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12112.159 | 0.1205 | -0.3586 | 1.8609 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 10518.14 | 1.0306 | 1.0506 | 1.2052 |