Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7526.067 | 0.0115 | -0.8279 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7526.067 | 0.0058 | -0.8826 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7527.067 | 0.9451 | 0.9420 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7527.067 | 0.9948 | 0.9946 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7527.067 | 0.9760 | 0.9749 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7527.067 | 1.0079 | 1.0082 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 7527.067 | 1.0175 | 1.0182 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7527.067 | 0.9359 | 0.9321 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7527.067 | 0.6407 | 0.5856 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7527.067 | 0.0085 | -0.8332 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7527.067 | 0.0048 | -0.8758 | 1.9179 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7528.067 | 1.0129 | 1.0276 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7528.067 | 1.0004 | 1.0008 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7528.067 | 1.0244 | 1.0521 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7528.067 | 1.0027 | 1.0058 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 7528.067 | 0.9901 | 0.9790 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7528.067 | 0.9366 | 0.8652 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7528.067 | 0.8082 | 0.5939 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7528.067 | 0.0087 | -0.9873 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7528.067 | 0.0007 | -0.9991 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 9044.067 | 1.0229 | 1.1460 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 9044.067 | 0.9831 | 0.8966 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 9044.067 | 0.7381 | -0.2234 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 9044.067 | 0.8282 | 0.1120 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 9044.067 | 1.2912 | 3.4340 | 0.3210 |