Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7485.067 | 0.8132 | 0.8930 | 3.7597 | |
| MCF 10A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7485.067 | 0.2511 | 0.3849 | 3.7597 | |
| MCF 10A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7485.067 | 0.0097 | -0.4175 | 3.7597 | |
| MCF 10A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7485.067 | 0.0056 | -0.4965 | 3.7597 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7487.067 | 1.0047 | 1.0070 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7487.067 | 1.0043 | 1.0064 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7487.067 | 1.0800 | 1.1172 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7487.067 | 1.0318 | 1.0468 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 7487.067 | 1.0499 | 1.0733 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7487.067 | 0.9879 | 0.9820 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7487.067 | 0.3545 | -0.0711 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7487.067 | 0.0465 | -0.7932 | 1.3523 | |
| MCF 10F | NM | - | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7487.067 | 0.0004 | -0.9938 | 1.3523 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7489.067 | 1.0624 | 1.0699 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7489.067 | 1.0866 | 1.0967 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7489.067 | 1.0575 | 1.0645 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0533 | uM | 7489.067 | 1.0751 | 1.0840 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.267 | uM | 7489.067 | 1.0656 | 1.0736 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 1.33 | uM | 7489.067 | 1.0893 | 1.0996 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 6.67 | uM | 7489.067 | 0.6204 | 0.5250 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 33.3 | uM | 7489.067 | 0.0100 | -0.8539 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 167 | uM | 7489.067 | 0.0023 | -0.9372 | 1.7603 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.000427 | uM | 7490.067 | 0.9178 | 0.9363 | 2.6472 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.00213 | uM | 7490.067 | 0.9960 | 0.9970 | 2.6472 | |
| MCF12A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 0.0107 | uM | 7490.067 | 1.0259 | 1.0194 | 2.6472 |