Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.0032 | uM | 12428.155 | 0.9940 | 0.9843 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.016 | uM | 12428.155 | 0.9864 | 0.9644 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.08 | uM | 12428.155 | 0.9473 | 0.8634 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.4 | uM | 12428.155 | 0.9151 | 0.7811 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 2 | uM | 12428.155 | 0.8282 | 0.5633 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 12428.155 | 0.6860 | 0.2224 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 12428.155 | 0.6642 | 0.1719 | 0.7654 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.000128 | uM | 10819.155 | 1.1107 | 1.1048 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.00064 | uM | 10819.155 | 0.9538 | 0.9545 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.0032 | uM | 10819.155 | 1.0027 | 1.0026 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.016 | uM | 10819.155 | 0.9424 | 0.9431 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.08 | uM | 10819.155 | 0.8070 | 0.8019 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.4 | uM | 10819.155 | 0.6083 | 0.5705 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 2 | uM | 10819.155 | 0.4483 | 0.3539 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 10819.155 | 0.2764 | 0.0701 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 10819.155 | 0.2570 | 0.0329 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.000128 | uM | 11937.155 | 0.9548 | 0.9630 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.00064 | uM | 11937.155 | 0.9439 | 0.9540 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.0032 | uM | 11937.155 | 0.8906 | 0.9087 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.016 | uM | 11937.155 | 0.8887 | 0.9070 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.08 | uM | 11937.155 | 0.7158 | 0.7476 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.4 | uM | 11937.155 | 0.6488 | 0.6796 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 2 | uM | 11937.155 | 0.4430 | 0.4400 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 11937.155 | 0.3826 | 0.3573 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 11937.155 | 0.3359 | 0.2878 | 2.4784 |