Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.201 | uM | 9163.011 | 1.0638 | 1.2075 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 9163.011 | 0.9222 | 0.7574 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 9163.011 | 0.8700 | 0.6013 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 9163.011 | 0.7652 | 0.3049 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 9163.011 | 0.3993 | -0.5380 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 9163.011 | 0.0400 | -0.9883 | 0.6266 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 9186.119 | 1.0413 | 1.1780 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00805 | uM | 9186.119 | 1.0682 | 1.2987 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.0403 | uM | 9186.119 | 1.0797 | 1.3512 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.201 | uM | 9186.119 | 0.9626 | 0.8456 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 9186.119 | 1.0224 | 1.0958 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 9186.119 | 0.9216 | 0.6838 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 9186.119 | 0.9060 | 0.6240 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 9186.119 | 0.5465 | -0.4407 | 0.4743 | |
| BT-483 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 9186.119 | 0.4613 | -0.6087 | 0.4743 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 7803.011 | 1.0308 | 1.0203 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00805 | uM | 7803.011 | 0.9918 | 0.9945 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.0403 | uM | 7803.011 | 1.0313 | 1.0206 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.201 | uM | 7803.011 | 0.8439 | 0.8903 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 1.01 | uM | 7803.011 | 0.4914 | 0.5794 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 5.03 | uM | 7803.011 | 0.2849 | 0.3178 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 7803.011 | 0.0186 | -0.4675 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 126 | uM | 7803.011 | 0.0073 | -0.6099 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 629 | uM | 7803.011 | 0.0023 | -0.7341 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 0.00161 | uM | 7804.011 | 1.0351 | 1.0288 | 2.4113 |