Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10579.087 | 0.8446 | 0.6779 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10579.087 | 0.7462 | 0.4754 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10579.087 | 0.5597 | 0.0941 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10579.087 | 0.3354 | -0.3575 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 0.267 | uM | 10579.087 | 0.3049 | -0.4181 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 1.33 | uM | 10579.087 | 0.3035 | -0.4208 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 6.67 | uM | 10579.087 | 0.2471 | -0.5322 | 0.9622 | |
| SUM225CWN | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 33.3 | uM | 10579.087 | 0.0655 | -0.8823 | 0.9622 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7535.087 | 0.9708 | 0.9443 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7535.087 | 0.8751 | 0.7612 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7535.087 | 0.7866 | 0.5910 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7535.087 | 0.5757 | 0.1816 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7535.087 | 0.3158 | -0.3333 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 0.267 | uM | 7535.087 | 0.1994 | -0.5699 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 1.33 | uM | 7535.087 | 0.1453 | -0.6820 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 6.67 | uM | 7535.087 | 0.0900 | -0.7984 | 1.0492 | |
| SUM229PE | TNBC | - | Omipalisib | PI3K | PI3K | 33.3 | uM | 7535.087 | 0.0648 | -0.8527 | 1.0492 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7539.087 | 0.9722 | 0.9542 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7539.087 | 0.9011 | 0.8358 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7539.087 | 0.8238 | 0.7052 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7539.087 | 0.4795 | 0.0925 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7539.087 | 0.3235 | -0.2097 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7539.087 | 0.2794 | -0.2996 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7539.087 | 0.2724 | -0.3140 | 1.2155 | |
| SUM52PE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7539.087 | 0.2508 | -0.3589 | 1.2155 |