Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 1.33 | uM | 7486.087 | 0.2007 | -0.4759 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 6.67 | uM | 7486.087 | 0.1918 | -0.4953 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 33.3 | uM | 7486.087 | 0.0590 | -0.8112 | 1.1994 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7490.086 | 0.9665 | 0.9728 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7490.086 | 0.8922 | 0.9104 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7490.086 | 0.7492 | 0.7808 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7490.086 | 0.5645 | 0.5893 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7490.086 | 0.2803 | 0.1995 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 7490.086 | 0.1353 | -0.1050 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 7490.086 | 0.1212 | -0.1438 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 7490.086 | 0.0724 | -0.3040 | 2.4876 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 7490.086 | 0.0315 | -0.5016 | 2.4876 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7493.086 | 1.0202 | 1.0451 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7493.086 | 0.9817 | 0.9593 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7493.086 | 0.9119 | 0.8048 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7493.086 | 0.7031 | 0.3514 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7493.086 | 0.3714 | -0.3358 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 7493.086 | 0.2125 | -0.6432 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 7493.086 | 0.1662 | -0.7285 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 7493.086 | 0.1696 | -0.7224 | 0.8986 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 7493.086 | 0.1511 | -0.7558 | 0.8986 | |
| MDA-MB-134-VI | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10419.087 | 0.9849 | 0.9560 | 0.6818 | |
| MDA-MB-134-VI | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10419.087 | 0.9073 | 0.7341 | 0.6818 | |
| MDA-MB-134-VI | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10419.087 | 0.8882 | 0.6807 | 0.6818 | |
| MDA-MB-134-VI | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10419.087 | 0.7892 | 0.4133 | 0.6818 |