Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 10379.087 | 0.1456 | -0.0914 | 2.4420 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10380.087 | 1.0703 | 1.1034 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10380.087 | 1.1433 | 1.2088 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10380.087 | 0.9740 | 0.9613 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10380.087 | 0.6867 | 0.5134 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10380.087 | 0.2728 | -0.2370 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10380.087 | 0.0683 | -0.7270 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10380.087 | 0.0443 | -0.8019 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10380.087 | 0.0517 | -0.7779 | 1.3481 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10380.087 | 0.0831 | -0.6842 | 1.3481 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7485.086 | 0.9596 | 0.9756 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7485.086 | 0.8464 | 0.9032 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7485.086 | 0.7326 | 0.8232 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7485.086 | 0.5083 | 0.6353 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7485.086 | 0.2553 | 0.3323 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 7485.086 | 0.1176 | 0.0579 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 7485.086 | 0.0743 | -0.0771 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 7485.086 | 0.0478 | -0.1909 | 3.3609 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 7485.086 | 0.0429 | -0.2162 | 3.3609 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7486.087 | 1.0418 | 1.0695 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.000427 | uM | 7486.087 | 0.8545 | 0.7543 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.00213 | uM | 7486.087 | 0.7119 | 0.5066 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.0107 | uM | 7486.087 | 0.4970 | 0.1165 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7486.087 | 0.2792 | -0.3097 | 1.1994 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.267 | uM | 7486.087 | 0.1963 | -0.4854 | 1.1994 |