Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10379.066 | 1.0384 | 1.0317 | 2.3931 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10379.066 | 0.9950 | 0.9958 | 2.3931 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10379.066 | 0.9673 | 0.9724 | 2.3931 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10379.066 | 0.8918 | 0.9065 | 2.3931 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10379.066 | 0.4187 | 0.3901 | 2.3931 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7477.066 | 1.1565 | 2.0634 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7477.066 | 0.9548 | 0.7464 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7477.066 | 1.2756 | 3.0842 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7477.066 | 1.1421 | 1.9528 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7477.066 | 0.9457 | 0.6977 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7477.066 | 1.7286 | 8.9593 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7477.066 | 1.0321 | 1.1941 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7477.066 | 0.3539 | -0.9050 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7477.066 | 0.0105 | -1.0000 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 10380.066 | 1.1150 | 1.1860 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 10380.066 | 1.1878 | 1.3017 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 10380.066 | 1.0860 | 1.1394 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 10380.066 | 1.1377 | 1.2222 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 10380.066 | 1.1524 | 1.2457 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 10380.066 | 0.9748 | 0.9587 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 10380.066 | 0.8248 | 0.7089 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 10380.066 | 0.4129 | -0.0288 | 1.2245 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 10380.066 | 0.0497 | -0.8275 | 1.2245 | |
| MB 157 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7482.066 | 1.0620 | 1.1089 | 1.1347 | |
| MB 157 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7482.066 | 1.1735 | 1.3029 | 1.1347 |