Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7466.066 | 1.0523 | 1.1111 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7466.066 | 1.0706 | 1.1502 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7466.066 | 1.0333 | 1.0708 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7466.066 | 1.0340 | 1.0722 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7466.066 | 0.9899 | 0.9786 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7466.066 | 0.6002 | 0.1633 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7467.066 | 0.9748 | 0.9578 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7467.066 | 0.9743 | 0.9569 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7467.066 | 0.9999 | 0.9998 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7467.066 | 0.9427 | 0.9037 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7467.066 | 1.0017 | 1.0028 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7467.066 | 0.9832 | 0.9719 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7467.066 | 0.9865 | 0.9773 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7467.066 | 0.9315 | 0.8847 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7467.066 | 0.2624 | -0.3469 | 1.1956 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7468.066 | 0.9040 | 0.8603 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7468.066 | 0.9507 | 0.9287 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7468.066 | 0.9691 | 0.9555 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7468.066 | 0.9697 | 0.9564 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7468.066 | 0.9787 | 0.9694 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7468.066 | 0.9281 | 0.8958 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7468.066 | 0.9457 | 0.9214 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7468.066 | 0.8253 | 0.7426 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7468.066 | 0.1119 | -0.5845 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7469.066 | 0.9558 | 0.9554 | 2.0057 |