Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10816.148 | 0.2341 | -0.7187 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10816.148 | 0.2206 | -0.7404 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12319.135 | 1.0031 | 1.0162 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12319.135 | 0.9822 | 0.9079 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12319.135 | 0.9893 | 0.9442 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12319.135 | 1.0982 | 1.5578 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12319.135 | 0.7425 | -0.0852 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12319.135 | 0.3912 | -0.8301 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12319.135 | 0.2742 | -0.9332 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12319.135 | 0.2809 | -0.9288 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12319.135 | 0.2515 | -0.9468 | 0.3806 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12580.135 | 1.0126 | 1.0115 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12580.135 | 0.9848 | 0.9860 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12580.135 | 0.9620 | 0.9647 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12580.135 | 1.0082 | 1.0076 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12580.135 | 0.8062 | 0.8116 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12580.135 | 0.4108 | 0.3293 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12580.135 | 0.3258 | 0.1952 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12580.135 | 0.2775 | 0.1102 | 2.1782 | |
| MB 157 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12580.135 | 0.2860 | 0.1257 | 2.1782 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11056.135 | 0.9218 | 0.9456 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11056.135 | 1.0327 | 1.0219 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11056.135 | 0.9610 | 0.9732 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11056.135 | 0.9112 | 0.9380 | 2.9533 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11056.135 | 0.6737 | 0.7497 | 2.9533 |