Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9118.019 | 0.9617 | 0.9284 | 1.0707 | ||
| 600MPE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9118.019 | 0.1820 | -0.5926 | 1.0707 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7793.016 | 0.9621 | 0.9345 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7793.016 | 0.9450 | 0.9049 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7793.016 | 0.9778 | 0.9617 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7793.016 | 0.9595 | 0.9300 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7793.016 | 0.9996 | 0.9993 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7793.016 | 0.9314 | 0.8813 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7793.016 | 0.8176 | 0.6816 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7793.016 | 0.8354 | 0.7132 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7793.016 | 0.0495 | -0.8497 | 1.1616 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7794.016 | 1.0541 | 1.0547 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7794.016 | 0.9024 | 0.8976 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7794.016 | 1.0422 | 1.0428 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7794.016 | 1.0010 | 1.0011 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7794.016 | 1.0490 | 1.0496 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7794.016 | 0.9399 | 0.9375 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 7794.016 | 0.8308 | 0.8190 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 7794.016 | 0.2935 | 0.0679 | 1.9541 | ||
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 7794.016 | 0.7456 | 0.7210 | 1.9541 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7797.016 | 0.9719 | 0.8925 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7797.016 | 0.9519 | 0.8176 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7797.016 | 0.8963 | 0.6174 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7797.016 | 0.8871 | 0.5852 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7797.016 | 0.8639 | 0.5059 | 0.5155 |