Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7485.098 | 0.9604 | 0.9762 | 3.3725 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7485.098 | 1.0042 | 1.0025 | 3.3725 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7485.098 | 0.8653 | 0.9160 | 3.3725 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7485.098 | 0.2589 | 0.3398 | 3.3725 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7486.098 | 1.0899 | 1.1969 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7486.098 | 0.9993 | 0.9984 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7486.098 | 0.9887 | 0.9753 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7486.098 | 1.1257 | 1.2759 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7486.098 | 1.1111 | 1.2436 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7486.098 | 0.9971 | 0.9936 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7486.098 | 1.0390 | 1.0852 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7486.098 | 1.0225 | 1.0492 | 0.9165 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7486.098 | 0.5107 | -0.0393 | 0.9165 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7492.098 | 0.9959 | 0.9948 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7492.098 | 0.9106 | 0.8842 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7492.098 | 1.0292 | 1.0370 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7492.098 | 1.0111 | 1.0142 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7492.098 | 1.0070 | 1.0090 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7492.098 | 0.9954 | 0.9941 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7492.098 | 0.9586 | 0.9468 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7492.098 | 0.9536 | 0.9404 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7492.098 | 0.9565 | 0.9442 | 1.5701 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7493.098 | 0.9999 | 0.9998 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7493.098 | 0.9523 | 0.9050 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7493.098 | 0.9220 | 0.8448 | 1.0051 |